CausalMechanismQualifierEnum
None
URI: CausalMechanismQualifierEnum
Permissible Values
| Value | Meaning | Description | Info |
|---|---|---|---|
| binding | None | A causal mechanism mediated by the direct contact between effector and target chemical or biomolecular entity, which form a stable physical interaction. | |
| inhibition | None | A causal mechanism in which the effector binds to the target and negatively effects its normal function, e.g. prevention of enzymatic reaction or activation of downstream pathway. | |
| antibody inhibition | None | A causal mechanism in which an antibody specifically binds to and interferes with the target. | |
| antagonism | None | A causal mecahnism in which the effector binds to a receptor and prevents activation by an agonist through competing for the binding site. | |
| molecular channel blockage | None | A causal mechanism in which the effector binds to a molecular channel and prevents or reduces transport of ions through it. | |
| inverse agonism | None | A causal mechanism in which the effector binds to the same receptor-binding site as an agonist and antagonizes its effects, often exerting the opposite effect of the agonist by suppressing spontaneous receptor signaling. | |
| negative allosteric modulation | None | A causal mechanism in which the effector reduces or prevents the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition) | |
| agonism | None | A causal mechanism in which the effector binds and activates a receptor to mimic the effect of an endogenous ligand. | |
| molecular channel opening | None | A causal mechanism in which the effector binds to a molecular channel and facilitates transport of ions through it. | |
| positive allosteric modulation | None | A causal mechanism in which the effector enhances the action of the endogenous ligand of a receptor by binding to a site distinct from that ligand (i.e. non-competitive inhibition) | |
| potentiation | None | A causal mechanism in which the effector binds to and enhances or intensifies the effect of some other chemical or drug on its target. | |
| activation | None | A causal mechanism in which the effector binds to and positively affects the normal functioning of its target. | |
| inducer | None | A causal mechanism in which the effector binds to and increases the activity/rate of an enzyme that processes drugs in the body. | |
| transcriptional regulation | None | A causal mechanism mediated by through the control of target gene transcription | |
| signaling-mediated control | None | A causal mechanism mediated by the activation or control of signaling events that influence the some aspect of the target entity (e.g. its activity, processing, transport, etc) |